Diarrhoea is a major health problem especially for children under the age of 5 and up to 17% of children admitted in the paediatric ward die of diarrhea. A range of medicinal plants with anti-diarrhoeal properties is widely used by traditional healers. The antidiarrhoeal effect of the water extract of Allium Sativum Linn., leaves were investigated by employing four experimental models of diarrhea in wister albino rats. Loperamide (3 mg/kg, p.o.) was taken as standard, aqueous bulb extract of Allium sativam 150 & 300 mg/kg was used as a test doses. The water extract of Allium Sativum treated mice showed significant reduction in the faecal output and protected them from castor oil-induced diarrhoea. The extract tested at 150 and 300 mg/kg shown similar effect as that of standard drug (loperamide) by significantly inhibiting the frequency of defecation droppings compared to untreated control rats. Results obtained in this study substantiate the antidiarrheal effect of the aqueous extract of Bryophyllum pinnatum leaves and its use by traditional practitioners in the treatment of diarrhoea.
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